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Please see my answers below in green:
best,
Hani

1- my sister has scholarship from ministry of higher education ( King Abdullah schoalrship ) but the problem is my sister has not receive the I-20 yet !! should i wait ? or can i take appointment? because i do not know from which university the ministry of higher education gonna issue the I-20 from !!
No need to wait, when you fill the DS-160 write any information regarding the university and address. For the SEVIS # enter N0000000000


2- My brother (Adel ******) was not able to upload the picture on line !! so is it okay to bring it to the embassy or does he he has to upload it online?
No problem, he can get the picture with him to the Embassy.


3- My brother (Adel ******) already have his I-20 with him ( English program only), and his official certificate for high school with Cleveland State university because they are going to issue conditional admission for him so they need it official !! does he have to bring it to the embassy? or colored copy is enough ?? Thank you so
No problem he should get what is available: copy, email, etc no need to print in color.